Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting In Cd8+ T Cell Memory And Delayed Tumor Progression, 2020 Iowa State University 81818app手机版下载
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting In Cd8+ T Cell Memory And Delayed Tumor Progression, Ross Darling, Sujata Senapati, John Christiansen, Luman Liu, Amanda E. Ramer-Tait, Balaji Narasimhan, Michael J. Wannemeuhler
Chemical and Biological Engineering Publications
Introduction: Adjuvants and immunotherapies designed to activate adaptive immunity to eliminate infectious disease and tumors have become an area of interest aimed at providing a safe and effective strategy to prevent or eliminate disease. Existing approaches would benefit from the development of immunization regimens capable of inducing efficacious cell-mediated immunity directed toward CD8+ T cell-specific antigens. This goal is critically dependent upon appropriate activation of antigen-presenting cells (APCs) most notably dendritic cells (DCs). In this regard, polyanhydride particles have been shown to be effectively internalized by APCs and induce activation.
Methods:81818app手机版下载 Here, a prophylactic vaccine regimen designed as a single-dose ...
Effects Of Period And Temperature On Quality And Shelf-Life Of Cucumber And Garden-Eggs Packaged Using Cassava Starch-Zinc Nanocomposite Film, 2020 Kwara State University, Malete
Effects Of Period And Temperature On Quality And Shelf-Life Of Cucumber And Garden-Eggs Packaged Using Cassava Starch-Zinc Nanocomposite Film, Adeshina Fadeyibi, Zinash Delebo Osunde, Mohammed Gana Yisa
Journal of Applied Packaging Research
Nanocomposite film can be used to prolong the shelf-life of fruits and vegetables. This research was undertaken to investigate the effects of packaging period and temperature on the quality and self-lives of cucumber and garden-eggs packaged using cassava starch-zinc nanocomposite film. Hundred grams each of cucumber and garden-eggs were wrapped in a 200× 350 mm size nanocomposite film and low density polyethylene (LDPE) of 2.240± 1.076 × 10-10 gm-1Pa-1s-1 water vapor and 1.568± 0.084× 10-10 gm-1Pa-1s-1 oxygen gas permeability. The products were stored at 10 ...
Designing A Reactor Chamber For Hot Electron Chemistry On Bimetallic Plasmonic Nanoparticles, 2020 Chapman University 81818app手机版下载
Designing A Reactor Chamber For Hot Electron Chemistry On Bimetallic Plasmonic Nanoparticles, Bryn Merrill, Bingjie Zhang, Jerry Larue
SURF Posters and Papers
81818app手机版下载Catalysis provides pathways for efficient and selective chemical reactions by lowering the energy barriers for desired products. Gold nanoparticles (AuNPs) show excellent promise as plasmonic catalysts. Plasmonic materials have localized surface plasmon resonances, oscillations of the electron bath at the surface of a nanoparticle, that generate energetically intense electric fields which rapidly decay into energetically excited electrons. The excited electrons have the potential to destabilize atoms strongly bound to the catalysts through occupation of antibonding orbitals. Tuning the antibonding orbitals to make them accessible for occupancy by electrons is achieved by coating the AuNP in a thin layer of another ...
Interfacial And Bulk Assembly Of Anisotropic Gold Nanostructures: Implications For Photonics And Plasmonics, 2020 Iowa State University and Ames Laboratory 81818app手机版下载
Interfacial And Bulk Assembly Of Anisotropic Gold Nanostructures: Implications For Photonics And Plasmonics, Hyeong Jin Kim, Md Mir Hossen, Andrew C. Hillier, David Vaknin, Surya K. Mallapragada, Wenjie Wang
Chemical and Biological Engineering Publications
We report on the assembly of polymer-grafted nanostructures at the vapor/aqueous interface and in bulk solutions by using synchrotron X-ray diffraction methods. Triangular- and octahedral-shaped gold nanostructures are synthesized and grafted with polyethylene glycol (referred to as PEG-AuNTs and PEG-AuNOh, respectively) and their suspensions are manipulated with salts, (poly)electrolytes that induce interpolymer complexation and HCl to achieve organized assemblies. The assemblies at the vapor/liquid interface are explored by X-ray reflectivity and grazing incidence small angle X-ray scattering. Results show that the PEG-AuNTs and PEG-AuNOh populate the interface, with some degree of orientation with respect to the liquid ...
Synthesis, Self-Assembly And High-Pressure Properties Of Nanoparticles And Hybrid Nanocomposites, 2020 University of New Mexico - Main Campus
Synthesis, Self-Assembly And High-Pressure Properties Of Nanoparticles And Hybrid Nanocomposites, Lingyao Meng
Nanoscience and Microsystems ETDs
81818app手机版下载Nanoparticles have gained significant scientific interests owing to their unique structural dimensions, size- and shape-tunable properties, and numerous fascinating applications, from opto-electronics, sensor devices, to energy, environmental, and medical fields. Furthermore, the synergistic integration of other materials, including organic polymers, with nanoparticles provides new opportunities and strategies to obtain nanocomposites with superior properties and functionalities. While there is already significant research on the synthesis and characterizations of nanoparticles and hybrid nanocomposites, some research questions, such as how to design and control the interfacial morphology in polymer/nanoparticle hybrid nanocomposites, how to synthesize metal- organic framework (MOF) nanoparticles in well-defined and ...
Transport Of Artificial Virus-Like Nanocarriers (Avn) Through Intestinal Monolayer Via Microfold Cells, 2020 Iowa State University
Transport Of Artificial Virus-Like Nanocarriers (Avn) Through Intestinal Monolayer Via Microfold Cells, Tianjian Tong, Yijun Qi, Luke Bussiere, Michael J. Wannemeuhler, Cathy L. Miller, Chenxu Yu, Qun Wang
Agricultural and Biosystems Engineering Publications
Compared with subcutaneous or intramuscular routes for vaccination, vaccine delivery via gastrointestinal mucosa has tremendous potential as it is easy to administer and pain free. Robust immune responses can be triggered successfully once vaccine carried antigen reaches the mucosal associated lymphoid sites (e.g., Peyer’s patches). However, the absence of an efficient delivery method has always been an issue for successful oral vaccine development. In our study, inspired by mammalian orthoreovirus (MRV) transport into gut mucosal lymphoid tissue via Microfold cells (M cells), artificial virus-like nanocarriers (AVN), consisting of gold nanocages functionalized with the 1 protein from mammalian reovirus ...
Surface Chemistry Of Ternary Nanocrystals: Engineering The Deposition Of Conductive Nabis2 Films, 2020 Iowa State University
Surface Chemistry Of Ternary Nanocrystals: Engineering The Deposition Of Conductive Nabis2 Films, Alan M. Medina-Gonzalez, Bryan A. Rosales, Umar H. Hamdeh, Matthew G. Panthani, Javier Vela
The ability to engineer the surface chemistry of complex ternary nanocrystals is critical to their successful application in photovoltaic, thermoelectric, and other energy conversion devices. For many years, several studies have shed light into the surface chemistry of unary and binary semiconductor nanocrystals, as well as their surface modification with monodentate and multidentate ligands in a variety of applications. In contrast, our understanding of the surface chemistry and ligand modification of ternary and other complex multinary nanocrystals remains relatively limited. Recently, our group reported the synthesis of colloidal NaBiS2 semiconductor nanocrystals with sizes tunable between 2–60 nm, and a ...
Direct Observations Of Field-Intensity-Dependent Dielectric Breakdown Mechanisms In Tio2 Single Nanocrystals, 2020 Iowa State University
Direct Observations Of Field-Intensity-Dependent Dielectric Breakdown Mechanisms In Tio2 Single Nanocrystals, Xinchun Tian, Geoff Lee Brennecka, Xiaoli Tan
Materials Science and Engineering Publications
One of the main challenges for next-generation electric power systems and electronics is to avoid premature dielectric breakdown in insulators and capacitors and to ensure reliable operations at higher electric fields and higher efficiencies. However, dielectric breakdown is a complex phenomenon and often involves many different processes simultaneously. Here we show distinctly different defect-related and intrinsic breakdown processes by studying individual, single-crystalline TiO2 nanoparticles using in situ transmission electron microscopy (TEM). As the applied electric field intensity rises, rutile-to-anatase phase transition, local amorphization/melting, and ablation are identified as the corresponding breakdown processes, the field intensity thresholds of which are ...
Transcriptome Studies On The Toxicity Of Silica Nanoparticles, 2020 University of South Florida
Transcriptome Studies On The Toxicity Of Silica Nanoparticles, Shih-Yi Hsu
Graduate Theses and Dissertations
81818app手机版下载Nanotechnology enables more precise harmony in health condition via reducing the dosage amount, improving the delivery of hydrophobic drugs, more specific targeting to the cancerous sites, and so on. Nevertheless, issues regarding the toxicity of nanotechnology have begun to call for attention several decades later after the innovation of nanotechnology. Tools about risk management of nanotechnology have been developed, but recently not much evidence recognizes the toxicity of nanoparticles (NPs) except for some animal studies, which demonstrated organ damage after the exposure to NPs. Toxicogenomic approach refers to the method utilizing gene expression to evaluate the chemical toxicity. Databases as ...
Facile Fabrication Of Hierarchical Mof–Metal Nanoparticle Tandem Catalysts For The Synthesis Of Bioactive Molecules, 2020 Iowa State University and Zhejiang University 81818app手机版下载
Facile Fabrication Of Hierarchical Mof–Metal Nanoparticle Tandem Catalysts For The Synthesis Of Bioactive Molecules, Jingwen Chen, Biying Zhang, Long Qi, Yuchen Pei, Renfeng Nie, Patrick M. Heintz, Xuechen Luan, Zongbi Bao, Qiwei Yang, Qilong Ren, Zhiguo Zhang, Wenyu Huang
81818app手机版下载Multifunctional metal–organic frameworks (MOFs) that possess permanent porosity are promising catalysts in organic transformation. Herein, we report the construction of a hierarchical MOF functionalized with basic aliphatic amine groups and polyvinylpyrrolidone-capped platinum nanoparticles (Pt NPs). The postsynthetic covalent modification of organic ligands increases basic site density in the MOF and simultaneously introduces mesopores to create a hierarchically porous structure. The multifunctional MOF is capable of catalyzing a sequential Knoevenagel condensation–hydrogenation–intramolecular cyclization reaction. The unique selective reduction of the nitro group to intermediate hydroxylamine by Pt NPs supported on MOF followed by intramolecular cyclization with a cyano group ...
Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, 2020 Ohio Agricultural Research and Development Center and The Ohio State University 81818app手机版下载
Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya
Chemical and Biological Engineering Publications
Poor induction of mucosal immunity in the intestines by current Salmonella vaccines is a challenge to the poultry industry. We prepared and tested an oral deliverable Salmonella subunit vaccine containing immunogenic outer membrane proteins (OMPs) and flagellin (F) protein loaded and F-protein surface coated chitosan nanoparticles (CS NPs) (OMPs-F-CS NPs). The OMPs-F-CS NPs had mean particle size distribution of 514 nm, high positive charge and spherical in shape. In vitro and in vivo studies revealed the F-protein surface coated CS NPs were specifically targeted to chicken immune cells. The OMPs-F-CS NPs treatment of chicken immune cells upregulated TLRs, and Th1 ...
Fabrication Of Nanoscale Columnar Diodes By Glancing Angle Deposition, 2020 Macalester College
Fabrication Of Nanoscale Columnar Diodes By Glancing Angle Deposition, Jacob D. Weightman
Macalester Journal of Physics and Astronomy
81818app手机版下载Glancing angle deposition (GLAD) is a process in which thin films are deposited onto a substrate with obliquely incident vapor together with precisely controlled azimuthal substrate rotation. Ballistic shadowing effects due to the oblique incidence produce nanoscale structures, and a variety of feature shapes, including tilted columns, helices, and vertical columns can be achieved by varying the azimuthal rotation during the deposition process. Due to this control of morphology and the compatibility of the process with a wide variety of materials, GLAD films have found applications in a variety of fields including sensing, photonics, photovoltaics, and catalysis, where they are ...
Characterization Of Avidin And Case9 Single Protein Molecules By A Solid-State Nanopore Device, 2020 University of Arkansas, Fayetteville
Characterization Of Avidin And Case9 Single Protein Molecules By A Solid-State Nanopore Device, Haopeng Li
Theses and Dissertations
The shape and charge of a protein play significant roles in protein dynamics in the biological system of humans and animals. Characterizing and quantifying the shape and charge of a protein at the single-molecule level remains a challenge. Solid-state nanopores made of silicon nitride (SiNx) have emerged as novel platforms for biosensing such as diagnostics for single-molecule detection and DNA sequencing. SSN detection is based on measuring the variations in ionic conductance as charged biomolecules translocate through nanometer-sized channels driven by an external voltage applied across the membrane. In this paper, we observe the translocation of asymmetric cylindrical structure CRISPR-Cas9 ...
Probing Nanoelectroporation And Resealing Of The Cell Membrane By The Entry Of Ca2+ And Ba2+ Ions, 2020 Old Dominion University 81818app手机版下载
Probing Nanoelectroporation And Resealing Of The Cell Membrane By The Entry Of Ca2+ And Ba2+ Ions, Wenfei Bo, Mantas Silkunas, Uma Mangalanathan, Vitalij Novickij, Maura Casciola, Iurii Semenov, Shu Xiao, Olga N. Pakhomova, Andrei G. Pakhomov
The principal bioeffect of the nanosecond pulsed electric field (nsPEF) is a lasting cell membrane permeabilization, which is often attributed to the formation of nanometer-sized pores. Such pores may be too small for detection by the uptake of fluorescent dyes. We tested if Ca2+, Cd2+, Zn2+, and Ba2+ ions can be used as nanoporation markers. Time-lapse imaging was performed in CHO, BPAE, and HEK cells loaded with Fluo-4, Calbryte, or Fluo-8 dyes. Ca2+ and Ba2+ did not change fluorescence in intact cells, whereas their entry after nsPEF increased fluorescence within <1 ms. The threshold for one 300-ns pulse was at 1.5–2 kV/cm, much lower than >7 kV/cm for ...1>
Size-Dependent Inhibitory Effects Of Antibiotic Nanocarriers On Filamentation Of E. Coli, 2020 Old Dominion University 81818app手机版下载
Size-Dependent Inhibitory Effects Of Antibiotic Nanocarriers On Filamentation Of E. Coli, Preeyaporn Songkiatisak, Feng Ding, Pavan Kumar Cherukuri, Xiao-Hong Nancy Xu
Chemistry & Biochemistry Faculty Publications
Multidrug membrane transporters exist in both prokaryotic and eukaryotic cells and cause multidrug resistance (MDR), which results in an urgent need for new and more effective therapeutic agents. In this study, we used three different sized antibiotic nanocarriers to study their mode of action and their size-dependent inhibitory effects against Escherichia coli (E. coli). Antibiotic nanocarriers (AgMUNH–Oflx NPs) with 8.6 × 102, 9.4 × 103 and 6.5 × 105 Oflx molecules per nanoparticle (NP) were prepared by functionalizing Ag NPs (2.4 ± 0.7, 13.0 ± 3.1 and 92.6 ± 4.4 nm) with a ...
Crystallographic Facet Selective Her Catalysis: Exemplified In Fep And Nip2 Single Crystals, 2020 Iowa State University and Ames Laboratory
Crystallographic Facet Selective Her Catalysis: Exemplified In Fep And Nip2 Single Crystals, Bryan Owens-Baird, Juliana P.S. Sousa, Yasmine Ziouani, Dmitri Y. Petrovykh, Nikolai A. Zarkevich, Duane D. Johnson, Yury V. Kolen'ko, Kirill Kovnir
Ames Laboratory Accepted Manuscripts
How the crystal structures of ordered transition-metal phosphide catalysts affect the hydrogen-evolution reaction (HER) is investigated by measuring the anisotropic catalytic activities of selected crystallographic facets on large (mm-sized) single crystals of iron-phosphide (FeP) and monoclinic nickel-diphosphide (m-NiP2). We find that different crystallographic facets exhibit distinct HER activities, in contrast to a commonly held assumption of severe surface restructuring during catalytic activity. Moreover, density-functional-theory-based computational studies show that the observed facet activity correlates well with the H-binding energy to P atoms on specific surface terminations. Direction dependent catalytic properties of two different phosphides with different transition metals, crystal structures, and ...
Quantifying Wicking In Functionlized Surfaces, 2020 University of Nebraska - Lincoln
Quantifying Wicking In Functionlized Surfaces, Maureen Winter, Ryan Regan, Alfred Tsubaki, Craig Zuhlke, Dennis Alexander, George Gogos
UCARE Research Products
Wicking remains the enigmatic key factor in many research areas. From boiling in power plants, to anti-icing on plane wings, to medical instruments, to heat pipes, efficiency and safety depend on how quickly a surface becomes wet. Yet wicking remains difficult to quantify and define as a property of the surface. This experiment strives to measure the wicking property by examining the rate that a liquid can be pulled out of a container. A superhydrophilic surface is placed in contact with the liquid at the bottom of a tube so that the volume flow rate across the surface can be ...
Effective Dispersion Of Mgo Nanostructure On Biochar Support As A Basic Catalyst For Glucose Isomerization, 2020 The Hong Kong Polytechnic University and National Taiwan University 81818app手机版下载
Effective Dispersion Of Mgo Nanostructure On Biochar Support As A Basic Catalyst For Glucose Isomerization, Season S. Chen, Yang Cao, Daniel C.W. Tsang, Jean-Philippe Tessonnier, Jin Shang, Deyi Hou, Zhengtao Shen, Shicheng Zhang, Yong Sik Ok, Kevin C.-W. Wu
Chemical and Biological Engineering Publications
81818app手机版下载Glucose isomerization to fructose is one of the most important reactions in the field of biomass valorization. We demonstrate wood waste valorization with MgCl2 salt to synthesize an environment-friendly catalyst (i.e., MgO-biochar), which exhibits effective glucose-to-fructose isomerization with over 30% fructose yield and 80% selectivity at only 100 °C for 30 min in water as a green medium. This study highlights that one-step synthesis can effectively disperse and tether MgO nanostructures to the biochar matrix, which displays a significant reduction of Mg leaching compared to MgO-biochars produced by two-step synthesis and pure MgO. The MgCl2 acts as a porogen ...
Enhanced Carrier Transport By Transition Metal Doping In Ws2 Field Effect Transistors, 2020 State University of New York at Buffalo 81818app手机版下载
Enhanced Carrier Transport By Transition Metal Doping In Ws2 Field Effect Transistors, Maomao Liu, Sichen Wei, Simran Shahi, Hemendra Nath Jaiswal, Paolo Paletti, Sara Fathipour, Maja Remskar, Jun Jiao, Wansik Hwang, Fei Yao, Huamin Li
Physics Faculty Publications and Presentations
High contact resistance is one of the primary concerns for electronic device applications of two-dimensional (2D) layered semiconductors. Here, we explore the enhanced carrier transport through metal–semiconductor interfaces in WS2 field effect transistors (FETs) by introducing a typical transition metal, Cu, with two different doping strategies: (i) a “generalized” Cu doping by using randomly distributed Cu atoms along the channel and (ii) a “localized” Cu doping by adapting an ultrathin Cu layer at the metal–semiconductor interface. Compared to the pristine WS2 FETs, both the generalized Cu atomic dopant and localized Cu contact decoration can provide a ...
Highly Transmissive Scalable Colored Coatings For Architectural Photovoltaic Panels, 2020 Old Dominion University
Highly Transmissive Scalable Colored Coatings For Architectural Photovoltaic Panels, Akbar Ali Syed
Electrical & Computer Engineering Theses & Disssertations
Highly transmissive coatings were developed by fabricating thin films using SiO2 and SiO2/TiO2 core/shell nanoparticles on glass substrates and on the photovoltaic cell glass covers. This coating is to maintain an attractive color appearance of the exterior surface for architecturally integrated photovoltaics and can be coated on fabricated photovoltaic panels. The color and optical properties of the nanoparticle coating was investigated for different nanoparticle diameters of 200-400 nm for SiO2 nanoparticles and core/shell nanoparticles having SiO2/TiO2 structure with 300 ± 11 nm diameter, and SiO2/TiO2/SiO2 structure ...