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Mitochondrial Aspects Of Neuronal Pathology In Triple-Transgenic Alzheimer’S Disease Mice, John Zachary Cavendish 2021 West Virginia University

Mitochondrial Aspects Of Neuronal Pathology In Triple-Transgenic Alzheimer’S Disease Mice, John Zachary Cavendish

Graduate Theses, Dissertations, and Problem Reports

81818app手机版下载Alzheimer’s disease (AD) is a fatal, progressive neurodegenerative disease afflicting millions of people in the United States alone and is the only one of the top leading causes of morbidity and mortality with no effective disease-modifying therapies. It is the most common form of dementia, affecting one in three people over the age of 85. While the hallmarks of the disease include accumulation of beta-amyloid-based extracellular plaques and hyperphosphorylated tau-based intracellular neurofibrillary tangles, treatment strategies centered on removing or mitigating these components of AD have all failed in humans. Mitochondrial dysfunction has been increasingly recognized as an early and ...


Cortical Iron Disrupts Functional Connectivity Networks Supporting Working Memory Performance In Older Adults, Valentinos Zachariou, Christopher E. Bauer, Elayna R. Seago, Flavius D. Raslau, David K. Powell, Brian T. Gold 2020 University of Kentucky

Cortical Iron Disrupts Functional Connectivity Networks Supporting Working Memory Performance In Older Adults, Valentinos Zachariou, Christopher E. Bauer, Elayna R. Seago, Flavius D. Raslau, David K. Powell, Brian T. Gold

Neuroscience Faculty Publications

81818app手机版下载Excessive brain iron negatively affects working memory and related processes but the impact of cortical iron on task-relevant, cortical brain networks is unknown. We hypothesized that high cortical iron concentration may disrupt functional circuitry within cortical networks supporting working memory performance. Fifty-five healthy older adults completed an N-Back working memory paradigm while functional magnetic resonance imaging (fMRI) was performed. Participants also underwent quantitative susceptibility mapping (QSM) imaging for assessment of non-heme brain iron concentration. Additionally, pseudo continuous arterial spin labeling scans were obtained to control for potential contributions of cerebral blood volume and structural brain images were used to control ...


Tonic And Phasic Amperometric Monitoring Of Dopamine Using Microelectrode Arrays In Rat Striatum, Martin Lundblad, David A. Price, Jason J. Burmeister, Jorge E. Quintero, Peter Huettl, Francois Pomerleau, Nancy R. Zahniser, Greg A. Gerhardt 2020 University of Kentucky

Tonic And Phasic Amperometric Monitoring Of Dopamine Using Microelectrode Arrays In Rat Striatum, Martin Lundblad, David A. Price, Jason J. Burmeister, Jorge E. Quintero, Peter Huettl, Francois Pomerleau, Nancy R. Zahniser, Greg A. Gerhardt

Neuroscience Faculty Publications

Here we report a novel microelectrode array recording approach to measure tonic (resting) and phasic release of dopamine (DA) in DA-rich areas such as the rat striatum and nucleus accumbens. The resulting method is tested in intact central nervous system (CNS) and in animals with extensive loss of the DA pathway using the neurotoxin, 6-hydroxyDA (6-OHDA). The self-referencing amperometric recording method employs Nafion-coated with and without m-phenylenediamine recording sites that through real-time subtraction allow for simultaneous measures of tonic DA levels and transient changes due to depolarization and amphetamine-induced release. The recording method achieves low-level measures of both tonic and ...


Winning In Weight-Loss: The Interaction Of Conscientiousness And Perceived Autonomy, Jason M. Curtis, Marc Lochbaum 2020 Rocky Mountain University of Health Professions

Winning In Weight-Loss: The Interaction Of Conscientiousness And Perceived Autonomy, Jason M. Curtis, Marc Lochbaum

NeuroSports

ABSTRACT

Background

81818app手机版下载Understanding determinants for weight-loss is a national priority. Obesity is an epidemic with serious health consequences. Most of today’s obesity and overweight problems are being attributed to poor diets and not enough physical activity. These problems show no signs of slowing down with the behaviors of most Americans. The phenomenon of “The Biggest Loser” (different variants of weight-loss programs that consist of group exercise participation and nutrition therapy to elicit weight-loss, and hopefully behavior change) has spawned many variants in commercial health clubs. This prospectus study examined the direct and interactive or moderated effects of known determinants ...


Optimizing Preprocessing Of Fmri Data To Maximize Correspondence Of Functional Anatomy Across Individuals, Nargess Ghazaleh 2020 The University of Western Ontario

Optimizing Preprocessing Of Fmri Data To Maximize Correspondence Of Functional Anatomy Across Individuals, Nargess Ghazaleh

Electronic Thesis and Dissertation Repository

81818app手机版下载In movie-activation fMRI, intersubject correlation (ISC) indicates a functional correspondence across viewers. Brains differ in shape; spatial normalization and smoothing enhance inter-subject functional overlap. We compare 3 normalization methods (SPM12, DARTEL and ANTS) and 6 smoothing levels to discover which method yields the best functional overlap, indexed by ISC. This is key to optimizing data analysis in clinical studies using movie-activation fMRI in future. In a 3T scanner, 44 healthy subjects watched an 8-min movie. Both normalization and smoothing affected the strength and extent of the ISC. ISC values were more robust for ANTs and DARTEL than for SPM12 and ...


Neurodevelopmental Mechanisms Of Adverse Trauma Outcomes In Emerging Adulthood, Olena Kleshchova 2020 The Graduate Center, City University of New York

Neurodevelopmental Mechanisms Of Adverse Trauma Outcomes In Emerging Adulthood, Olena Kleshchova

Dissertations, Theses, and Capstone Projects

Background: Exposure to traumatic stress and adversity during the formative years of development can have adverse effects on mental health, neuroendocrine stress system function, and the brain, that persist into adulthood. One candidate mechanism that might confer vulnerability to enduring adverse outcomes of early life trauma is disruption of normal brain maturation. As the brain matures, functional interactions among brain regions change until the functional brain architecture (i.e., the functional connectome) reaches a mature state in adulthood. Given that different neural circuits have distinct developmental trajectories and sensitive periods, traumatic stress at a given point in development might have ...


Investigating The Role Of Phox2b-Expressing Glutamatergic Parafacial Zone Neurons In Sleep Wake Control, Evelyn T. M. Erickson 2020 University of Massachusetts Medical School

Investigating The Role Of Phox2b-Expressing Glutamatergic Parafacial Zone Neurons In Sleep Wake Control, Evelyn T. M. Erickson

GSBS Dissertations and Theses

Inhibitory GABAergic neurons in the parafacial zone (PZGABA) are essential for slow wave sleep (SWS). Since existing literature about the heterogenous population of PZ neurons is lacking, questions remain regarding the non-GABAergic sleep active PZ neurons. This study seeks to determine if glutamatergic PZ neurons expressing the transcription factor Phox2B (PZPhox2B) participate in sleep-wake control. Phox2B-IRES-Cre mice received injections of adeno-associated virus containing Cre-dependent diphtheria toxin subunit A (DTA) DNA into the PZ (PZPhox2B-DTA). Analysis of injection sites revealed transfection covering the PZ and the locus coeruleus, also known to express Phox2B. We recorded the ...


Methylmercury Cytotoxicity On Developing Neuronal Lineages And Differences In Susceptibility Based On Media Type, Madeline Henley 2020 Purdue University 81818app手机版下载

Methylmercury Cytotoxicity On Developing Neuronal Lineages And Differences In Susceptibility Based On Media Type, Madeline Henley

The Journal of Purdue Undergraduate Research

No abstract provided.


Characterization Of Neuronal Differentiation And Activity In Human-Induced Pluripotent Neural Stem Cells, Allison Biddinger 2020 Purdue University

Characterization Of Neuronal Differentiation And Activity In Human-Induced Pluripotent Neural Stem Cells, Allison Biddinger

The Journal of Purdue Undergraduate Research

No abstract provided.


The Effects Of Adolescent Chronic Mild Stress: In Female Wistar-Kyoto Rats, Anna Hallowell 2020 Purdue University

The Effects Of Adolescent Chronic Mild Stress: In Female Wistar-Kyoto Rats, Anna Hallowell

The Journal of Purdue Undergraduate Research

Despite years of research to understand under-lying mechanisms and develop more effective treatment approaches for mood disorders, numerous challenges exist. Many chronic stress models are used to study mood disorders, how-ever the majority have been established with adult males. This is problematic considering that affective disorders are more common in women, and generally develop during late adolescence. Studies have indicated fundamental behavioral, physiological, and neural differences between males and females in response to the same external stressors, furthering a need to develop sex-specific paradigms to accurately model the etiology of mood disorders in females. The Wistar-Kyoto (WKY) rat strain is ...


The Role Of The Leucine-Rich (Leur) Domain Of Rho Guanine Nucleotide Exchange Factor (Rgnef) In The Regulation Of Amyotrophic Lateral Sclerosis (Als) Associated Protein Tar Dna-Binding Protein Of 43 Kda (Tdp-43), Hind Amzil 2020 The University of Western Ontario

The Role Of The Leucine-Rich (Leur) Domain Of Rho Guanine Nucleotide Exchange Factor (Rgnef) In The Regulation Of Amyotrophic Lateral Sclerosis (Als) Associated Protein Tar Dna-Binding Protein Of 43 Kda (Tdp-43), Hind Amzil

Electronic Thesis and Dissertation Repository

The presence of neuronal cytoplasmic inclusions (NCIs) composed of RNA-binding proteins (RBPs) and neurofilaments is considered to be ALS’s neuropathological hallmark. RGNEF has been previously shown to interact with TDP-43 and to have a regulatory effect on the expression levels of NEFL mRNA and NFL protein in vitro81818app手机版下载. Here, I examined the mechanism of the RGNEF N-terminus, leucine-rich domain (LeuR) domain’s interaction with TDP-43. I observed that the minimal domain required is 110 amino acids (LeuR110), that the Ankyrin domain adjacent to LeuR110 does not participate, and that LeuR110 forms of a high molecular weight complex with TDP-43 ...


Methods For Detecting Per2::Luciferase Bioluminescence Rhythms In Freely Moving Mice, B. Martin-Burgos, W. Wang, I. William, S. Tir, I. Mohammad, R. Javed, Smith College, Y. Cui, Ciearra B. Smith, V. van der Vinne, P.C. Molyneux, Stephen C. Miller, David R. Weaver, T.L. Leise, M.E. Harrington 2020 Smith College 81818app手机版下载

Methods For Detecting Per2::Luciferase Bioluminescence Rhythms In Freely Moving Mice, B. Martin-Burgos, W. Wang, I. William, S. Tir, I. Mohammad, R. Javed, Smith College, Y. Cui, Ciearra B. Smith, V. Van Der Vinne, P.C. Molyneux, Stephen C. Miller, David R. Weaver, T.L. Leise, M.E. Harrington

University of Massachusetts Medical School Faculty Publications

Circadian rhythms are driven by daily oscillations of gene expression. An important tool for studying cellular and tissue rhythms is the use of a gene reporter, such as bioluminescence from the reporter gene luciferase controlled by a rhythmically expressed gene of interest. Here we describe methods that allow measurement of bioluminescence from a freely-moving mouse housed in a standard cage. Using a LumiCycle In Vivo81818app手机版下载 (Actimetrics), we determined conditions that allow detection of circadian rhythms of bioluminescence from the PER2 reporter, PER2::LUC, in freely behaving mice. We tested delivery of D-luciferin via a subcutaneous minipump and in the drinking ...


Feeling-Of-Knowing Experiences Breed Curiosity, Gregory Brooks 2020 The University of Western Ontario 81818app手机版下载

Feeling-Of-Knowing Experiences Breed Curiosity, Gregory Brooks

Electronic Thesis and Dissertation Repository

It is well-established that curiosity has benefits for learning. Less is known about potential links between curiosity and memory retrieval. In theoretical work on metacognition it has been argued that retrieval experiences that occur during memory search can exert control over behaviour. States of curiosity, which can be defined as behavioural tendencies to seek out information, may play a critical role in this control function. We conducted two experiments to address this idea, focusing on links between feeling-of knowing (FOK) experiences, memory-search duration, and subsequent information-seeking behaviour. We administered an episodic FOK paradigm that probed memory for previously studied arbitrary ...


The Impact Of Multiliteracies And Multimodality On Esl Learners: Using Neuroimaging Technologies, Wenyu Huang 2020 The University of Western Ontario 81818app手机版下载

The Impact Of Multiliteracies And Multimodality On Esl Learners: Using Neuroimaging Technologies, Wenyu Huang

Electronic Thesis and Dissertation Repository

Educational neuroscience has become an important role in understanding education and the association with brain development. However, few previous studies have applied neuroimaging techniques to multiliteracies research, which is an important literacy pedagogy addressing multimodal learning and cultural and linguistic diversity. This study used functional near infrared spectroscopy (fNIRS) to investigate the association of multiliteracies learning on adult English Second Language (ESL) students’ performance through multimodal tasks.

81818app手机版下载Students’ multimodality background was collected through a technology questionnaire. Behavioural and fNIRS data were collected before and after multiliteracies learning. Results showed that there was no significance change in behavioural responses while the ...


Optimization And Validation Of A Modified Radial-Arm Water Maze Protocol Using A Murine Model Of Mild Closed Head Traumatic Brain Injury, Teresa Macheda, Kelly N. Roberts, Josh M. Morganti, David J. Braun, Adam D. Bachstetter 2020 University of Kentucky

Optimization And Validation Of A Modified Radial-Arm Water Maze Protocol Using A Murine Model Of Mild Closed Head Traumatic Brain Injury, Teresa Macheda, Kelly N. Roberts, Josh M. Morganti, David J. Braun, Adam D. Bachstetter

Spinal Cord and Brain Injury Research Center Faculty Publications

81818app手机版下载Cognitive impairments can be a significant problem after a traumatic brain injury (TBI), which affects millions worldwide each year. There is a need for establish reproducible cognitive assays in rodents to better understand disease mechanisms and to develop therapeutic interventions towards treating TBI-induced impairments. Our goal was to validate and standardize the radial arm water maze (RAWM) test as an assay to screen for cognitive impairments caused by TBI. RAWM is a visuo-spatial learning test, originally designed for use with rats, and later adapted for mice. The present study investigates whether test procedures, such us the presence of extra-maze cues ...


Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits In Mice, Hui Li, Hong Xu, Wen Wen, Liying Wu, Mei Xu, Jia Luo 2020 University of Kentucky

Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits In Mice, Hui Li, Hong Xu, Wen Wen, Liying Wu, Mei Xu, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Thiamine deficiency (TD) has detrimental effects on brain health and neurobehavioral development, and it is associated with many aging-related neurological disorders. To facilitate TD-related neuropsychological studies, we generated a TD mouse model by feeding a thiamine-deficient diet for 30 days, followed by re-feeding the control diet for either one week or 16 weeks as recovery treatment. We then performed neurobehavioral tests in these two cohorts: cohort of one week post TD treatment (1 wk-PTDT) and 16 weeks post TD treatment (16 wks-PTDT). The TD mice showed no significant difference from control in any tests in the 1 wk-PTDT cohort at ...


The Impact Of Emotional Information On Task Performance In Unimodal Vs. Cross-Modal Paradigms, Emma K. Stewart 2020 The University of Western Ontario 81818app手机版下载

The Impact Of Emotional Information On Task Performance In Unimodal Vs. Cross-Modal Paradigms, Emma K. Stewart

Electronic Thesis and Dissertation Repository

81818app手机版下载Emotional stimuli can disrupt or enhance task performance, and this may depend on the sensory modality involved. In unimodal paradigms (e.g. visual task-irrelevant stimuli during a visual task) emotional stimuli frequently produce distraction effects; it is unclear how emotion affects task performance in cross-modal paradigms (e.g. auditory stimuli during a visual task). This project explored task performance as a function of sensory modality and emotional valence. In Study 1, participants (N=50) completed a visual task in the presence of task-irrelevant negative and neutral images and sounds. Response times and accuracy were disrupted in the presence of visual ...


Upregulating Beta-Hexosaminidase Activity In Rodents Prevents Alpha-Synuclein Lipid Associations And Protects Dopaminergic Neurons From Alpha-Synuclein-Mediated Neurotoxicity, Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett 2020 Harvard Medical School

Upregulating Beta-Hexosaminidase Activity In Rodents Prevents Alpha-Synuclein Lipid Associations And Protects Dopaminergic Neurons From Alpha-Synuclein-Mediated Neurotoxicity, Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. Macbain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett

Open Access Articles

Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of beta-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson's disease (PD). alpha-synuclein (aSYN) inclusions, the diagnostic hallmark sign of PD, are frequently found in the brain in SD patients and HEX knockout mice, and HEX activity is reduced in the substantia nigra in PD. In this study, we biochemically demonstrate that HEX deficiency in mice causes formation of high-molecular weight (HMW) aSYN and ubiquitin in the brain. As expected from HEX enzymatic function requirements, overexpression in vivo of ...


Brainwaves And Intentions: The Readiness Potential And Its Relation To Free Will, Joanna Pak, Aaron Schurger, Adina Roskies, Pengbo Hu 2020 Chapman University 81818app手机版下载

Brainwaves And Intentions: The Readiness Potential And Its Relation To Free Will, Joanna Pak, Aaron Schurger, Adina Roskies, Pengbo Hu

SURF Posters and Papers

81818app手机版下载First discovered in 1965 by Kornhuber and Deecke, the readiness potential (RP) is a distinctive buildup of neural activity in motor areas of the brain that begins ~500 ms before voluntary movements. In 1983, Libet used the RP as the foundation for his argument against the existence of conscious free will. This argument became known as the classic model of the RP, which interprets the RP as a precursor to the conscious experience of volition and a quantifiable representation of unconscious brain activity preceding spontaneous movements. Although the classic model connected the RP to free will, the significance of the ...


Altered Micos Morphology And Mitochondrial Ion Homeostasis Contribute To Poly(Gr) Toxicity Associated With C9-Als/Ftd, Shuangxi Li, Zhihao Wu, Yu Li, Ishaq Tantray, Diego De Stefani, Andrea Mattarei, Gopinath Krishnan, Fen-Biao Gao, Hannes Vogel, Bingwei Lu 2020 Stanford University 81818app手机版下载

Altered Micos Morphology And Mitochondrial Ion Homeostasis Contribute To Poly(Gr) Toxicity Associated With C9-Als/Ftd, Shuangxi Li, Zhihao Wu, Yu Li, Ishaq Tantray, Diego De Stefani, Andrea Mattarei, Gopinath Krishnan, Fen-Biao Gao, Hannes Vogel, Bingwei Lu

Open Access Articles

Amyotrophic lateral sclerosis (ALS) manifests pathological changes in motor neurons and various other cell types. Compared to motor neurons, the contribution of the other cell types to the ALS phenotypes is understudied. G4C2 repeat expansion in C9ORF72 is the most common genetic cause of ALS along with frontotemporal dementia (C9-ALS/FTD), with increasing evidence supporting repeat-encoded poly(GR) in disease pathogenesis. Here, we show in Drosophila muscle that poly(GR) enters mitochondria and interacts with components of the Mitochondrial Contact Site and Cristae Organizing System (MICOS), altering MICOS dynamics and intra-subunit interactions. This impairs mitochondrial inner membrane structure, ion homeostasis ...